| A body map of somatic mutagenesis in morphologically normal human tissues |
Colon, Esophagus, Liver, Lung, Pancreas, Rectum, Small intestine, Stomach |
LCM |
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| Accurate identification of single nucleotide variants in whole genome amplified single cells |
Fibroblast |
Clone, MDA |
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| Accurate SNV detection in single cells by transposon-based whole-genome amplification of complementary strands |
Blood, Brain, Testicle |
META-CS |
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| Aging and neurodegeneration are associated with increased mutations in single human neurons |
Brain |
MDA |
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| Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability |
Brain |
Bulk |
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| Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue |
Prostate |
Bulk |
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| Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients |
Blood, Bone marrow |
Clone |
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| APOBEC mutagenesis is a common process in normal human small intestine |
Small intestine |
LCM |
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| Clonal dynamics of haematopoiesis across the human lifespan |
Blood, Bone marrow |
Clone |
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| Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue |
Colon, Liver |
Clone |
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| Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox |
Blood, Bone marrow, Small intestine |
Clone, PTA |
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| Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis |
Brain |
Clone, MDA |
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| Diverse mutational landscapes in human lymphocytes |
Blood, Bone marrow, Spleen, Tonsil |
Clone |
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| Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin |
Skin |
LCM |
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| Evolutionary histories of breast cancer and related clones |
Breast |
LCM |
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| Extensive heterogeneity in somatic mutation and selection in the human bladder |
Bladder |
LCM |
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| Inherent mosaicism and extensive mutation of human placentas |
Placenta |
Bulk, LCM |
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| iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations |
iPSC |
Clone |
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| Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions |
Embryonic stem cell |
Clone |
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| Macroscopic somatic clonal expansion in morphologically normal human urothelium |
Bladder, Ureter |
LCM |
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| Maintenance of genome sequence integrity in long- and short-lived rodent species |
Fibroblast |
MDA |
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| Mutation accumulation and developmental lineages in normal and Down syndrome human fetal haematopoiesis |
Blood, Bone marrow, Small intestine |
Clone |
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| Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells |
iPSC |
Clone |
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| One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin |
iPSC |
Clone |
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| Population dynamics of normal human blood inferred from somatic mutations |
Blood, Bone marrow |
Clone |
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| Precancerous liver diseases do not cause increased mutagenesis in liver stem cells |
Liver |
Clone |
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| Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity |
Blood |
Bulk |
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| Single molecule, quantitative detection of low-abundance somatic mutations by high- throughput sequencing |
Fibroblast, Liver |
SMM-Seq |
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| Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers |
Breast |
MDA |
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| Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking |
Lung |
MDA |
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| Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver |
Liver |
Clone, MDA |
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| Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan |
Blood |
MDA |
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| Somatic evolution in non-neoplastic IBD-affected colon |
Colon |
LCM |
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| Somatic genomic changes in single Alzheimer’s disease neurons |
Brain |
MDA, PTA |
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| Somatic inflammatory gene mutations in human ulcerative colitis epithelium |
Colon |
Clone |
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| Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
Skeletal muscle |
Clone |
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| Somatic mutation landscapes at single-molecule resolution |
Bladder, Blood, Brain, Colon, Testicle |
NanoSeq |
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| Somatic mutations and clonal dynamics in healthy and cirrhotic human liver |
Liver |
LCM |
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| Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity |
Heart |
MDA |
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| Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells |
iPSC |
Clone |
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| The genomic landscapes of individual melanocytes from human skin |
Skin |
G&T-Seq |
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| The mutational landscape of human somatic and germline cells |
Adipocytes, Adrenal gland, Bladder, Colon, Esophagus, Heart, Kidney, Liver, Lung, Pancreas, Prostate, Skin, Small intestine, Stomach, Testicle, Thyroid, Ureter |
LCM |
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| The mutational landscape of normal human endometrial epithelium |
Endometrium |
LCM |
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| Tissue-specific mutation accumulation in human adult stem cells during life |
Colon, Liver, Small intestine |
Clone |
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| Tobacco smoking and somatic mutations in human bronchial epithelium |
Lung |
Clone |
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| UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin |
Fibroblast, Skin |
Clone |
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| Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type |
Adipocytes, Kidney, Skin |
Clone |
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